We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
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9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
Most Useful Reviews
9
Effective for numbness
200 people found this helpful
Magnesium is one of the most vital minerals in the human body, essential for the nervous, cardiovascular, skeletal, and muscular systems. After my arm went numb at night, I started taking magnesium. Following just one tablet each morning, the numbness disappeared! I'm very pleased and would highly recommend it!
Read More
9
Improved sleep quality
79 people found this helpful
I purchased this magnesium for my mother, and she was quite pleased. Her sleep quality improved, and she felt more energised. The effect on her cardiovascular system was definitely positive.
Read More
9
Treatment recommendation
43 people found this helpful
A doctor recommended a high-protein, low-sugar diet rich in vitamins and minerals for chronic nasopharyngitis. Magnesium is crucial, and I take nine tablets daily while my wife takes twelve. This intake helps with my wife's migraines, as well as her ongoing treatment for a serious condition related to calcium. Overall, magnesium has made significant improvements in our health.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
8
Magnesium linked to heart health
Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes.
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
Read More
8
Magnesium impacts blood sugar control
Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.
We explored the connections between magnesium (Mg), calcium (Ca), and abnormal levels of HbA1c—a key marker for blood sugar management—in adults with coronary artery disease (CAD). Our research involved a substantial group of 11,934 patients, allowing us to gain valuable insights into how these minerals impact cardiovascular health.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
Read More
8
Magnesium's impact on HFpEF mortality
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Magnesium is one of the most vital minerals in the human body, essential for the nervous, cardiovascular, skeletal, and muscular systems. After my arm went numb at night, I started taking magnesium. Following just one tablet each morning, the numbness disappeared! I'm very pleased and would highly recommend it!
Read More
9
Improved sleep quality
79 people found this helpful
I purchased this magnesium for my mother, and she was quite pleased. Her sleep quality improved, and she felt more energised. The effect on her cardiovascular system was definitely positive.
Read More
9
Treatment recommendation
43 people found this helpful
A doctor recommended a high-protein, low-sugar diet rich in vitamins and minerals for chronic nasopharyngitis. Magnesium is crucial, and I take nine tablets daily while my wife takes twelve. This intake helps with my wife's migraines, as well as her ongoing treatment for a serious condition related to calcium. Overall, magnesium has made significant improvements in our health.
Read More
7.5
Effective chelated form
2 people found this helpful
This magnesium product is excellent for strengthening the cardiovascular system. It contains forms that are well absorbed and do not cause digestive issues. With its calming properties, it helps reduce headaches. I appreciate the quality of the product, despite the large tablets, as the benefits are worth it.
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9
Enhanced sleep quality
1 people found this helpful
From the very first day, this product helped my disrupted sleep and muscle tension. While I initially took two capsules, I now take one at night and find it effective. I'm used to the large pill size, and it's become a staple for my health.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is an essential mineral that plays a significant role in various bodily functions, including heart health. Research has shown that adequate magnesium intake can help regulate blood pressure, maintain normal heart rhythms, and support overall cardiovascular function. Some studies suggest that higher magnesium levels may be associated with a lower risk of cardiovascular disease, as magnesium helps to keep blood vessels dilated and can prevent harmful calcium buildup in arterial walls.
However, it’s important to note that while magnesium supplementation can be beneficial, it should not be seen as a standalone treatment for cardiovascular disease. A well-rounded approach that includes a balanced diet rich in magnesium (found in foods like leafy greens, nuts, seeds, and whole grains), regular physical activity, and maintaining a healthy weight is essential for optimal heart health. As always, it is best to consult with a healthcare provider before making any substantial changes to your diet or supplement routine, especially if you have existing heart conditions or other health concerns.
Based on user reviews, the time it takes to see results from magnesium supplements, particularly for cardiovascular health, can vary. Many users report noticing benefits within just a few days to a couple of weeks. For instance, one user mentioned significant improvements after taking magnesium for only a couple of weeks, specifically citing its impact on her daughter's migraine frequency (Read Review). Another noted that after starting magnesium, he experienced improvements in energy levels and a calming effect almost immediately (Read Review).
However, it's essential to recognize that individual experiences may differ, and some users have found that consistent use over a month or more is necessary before fully appreciating the cardiovascular and overall health benefits. For example, a reviewer emphasized the reduction of symptoms after a month of regular intake (Read Review). Therefore, while some might see benefits swiftly, others may require more sustained use to gauge significant effects on cardiovascular health.
Research increasingly supports the role of magnesium as a beneficial supplement in managing cardiovascular disease. One compelling study highlighted that higher serum magnesium levels significantly reduced the risk of cardiovascular mortality in patients with chronic kidney disease, suggesting that maintaining adequate magnesium levels is crucial for heart health [2]. Additionally, dietary magnesium intake has been associated with decreased risks of cardiovascular-related deaths in diabetic patients, indicating that increasing magnesium-rich foods could be a practical strategy for enhancing heart health [3].
Moreover, magnesium's potential extends to specific conditions; recent research indicated that magnesium supplementation may substantially lower mortality in heart failure patients, particularly older adults and those with hypertension [5]. However, the science isn't entirely settled, as some studies note that while magnesium can positively influence blood sugar regulation—a vital component in heart disease management—it doesn't act in isolation, and further investigation is needed to fully understand its complex interactions within the body [4]. Overall, the growing body of evidence positions magnesium as a noteworthy supplement in the discussion of cardiovascular health.
Many users have reported impressive improvements in their health symptoms after incorporating magnesium supplements into their routines. Several reviewers noted that magnesium has alleviated issues such as muscle tension and insomnia. For example, one satisfied user highlighted that their disrupted sleep and muscle tension improved significantly almost immediately after starting the supplement (Read Review). Similarly, another reviewer mentioned substantial improvements in shoulder stiffness and range of motion, which positively influenced their overall wellness (Read Review).
In terms of cardiovascular benefits, many users report feeling a sense of stability and calm in their heart health. One reviewer even noted a complete cessation of palpitations after adjusting their magnesium dosage, attributing it as a vital factor in their overall heart health strategy (Read Review). Notably, individuals have described improvements in sleep quality, energy levels, and anxiety reduction, with one mentioning an immediate enhancement in mood and sleep after starting the supplement for insomnia (Read Review). While these experiences are encouraging, it's important to remember that individual results can vary, and some may require more time or different dosages to achieve similar benefits.
Users report varying but generally positive experiences when combining magnesium supplements with other healthcare strategies for managing cardiovascular disease. Many individuals highlighted significant improvements in their heart health, attributing these effects to magnesium’s calming properties and its role in regulating muscle function, which includes the heart. For example, one user mentioned that they experienced a complete cessation of palpitations after increasing their magnesium intake along with other vitamins and minerals, describing magnesium as the missing link in their health regimen for cardiovascular support (Read Review). Another review emphasized the supplement's effectiveness in stabilizing heart function while also helping with nervous system health, showcasing its dual benefits in a comprehensive health plan (Read Review).
However, it is worth noting that some users faced issues when experimenting with their dosage. For instance, one reviewer reported experiencing restlessness in their heartbeat when they increased their intake, prompting them to adjust back to a lower dose (Read Review). Additionally, while many found magnesium beneficial when combined with other treatments for heart-related issues, one user advised against its use, sharing that they struggled with symptoms like arrhythmia after taking it (Read Review). Overall, user reviews indicate that magnesium can complement cardiovascular health, but individual responses and optimal dosages vary substantially.
Users report varying experiences regarding the dosage of magnesium for treating cardiovascular disease, emphasizing the importance of finding the right amount for individual needs. Some have found success with smaller doses, such as one or two capsules daily, while others have opted for significantly higher intakes, reporting between four to twelve tablets daily, based on specific health conditions or recommendations from healthcare providers. For instance, a user mentioned taking nine tablets daily for migraines and overall health improvement, while another user reported taking four to six tablets a day to alleviate severe palpitations Read ReviewRead Review.
Some users also highlighted their practice of adjusting dosages based on personal tolerance and effects, such as reducing intake after experiencing restlessness in heartbeat Read Review. The consensus seems to be that while it's essential to consult with a healthcare provider for proper dosing Read Review, a significant number of users noted a positive impact on their cardiovascular health with regular and sometimes high doses Read Review.
7.5
Migraines lessened
1 people found this helpful
Super! This isn’t the first time I’ve bought it for my daughter, who has suffered from migraines since school. She tried numerous migraine medications with little success. When I was recommended this chelated magnesium course, I ordered it right away. After taking 120 capsules—two in the morning and two in the evening—her migraines became much less frequent after a couple of weeks. As a mother, I am grateful as I was desperate to find a solution without constant painkillers. Now, I plan to have her continue taking this magnesium regularly, especially in the spring and autumn when migraines tend to worsen.
7.5
Quick relief experienced
2 people found this helpful
Magnesium is an important ally against fatigue, contributing significantly to my energy levels and cardiovascular health. It aids in muscle function and the prevention of cramps. The unique chelated form with amino acids ensures excellent absorption. After taking the recommended dosage, I felt an immediate calming effect, prompting me to adjust my intake to two capsules daily. Overall, I highly recommend it.
6
Nervous system improved
35 people found this helpful
This product has positively impacted my nervous system, alleviating anxiety. After a month of taking two tablets daily, I found a reduction in nighttime tension and my mother’s intercostal neuralgia symptoms eased.
9
Enhanced sleep quality
1 people found this helpful
From the very first day, this product helped my disrupted sleep and muscle tension. While I initially took two capsules, I now take one at night and find it effective. I'm used to the large pill size, and it's become a staple for my health.
7.5
Enhanced flexibility experienced
24 people found this helpful
After starting this supplement recommended by my chiropractor, I noticed significant improvements in shoulder stiffness and my overall range of motion. I wake up feeling better and have experienced fewer illnesses since using this product.
9
Palpitations stopped
15 people found this helpful
It worked wonders for me! I suffered from severe palpitations, but after taking 4-6 tablets per day, they completely ceased. I use it alongside other vitamins and minerals, but magnesium was the missing link for me.
9
Aids sleep issues
2 people found this helpful
I began taking magnesium for my spouse's minor heart problems, suggested by our doctor. As a result, I also started using it for my insomnia. The effects were immediate; I now sleep soundly and wake refreshed. While I initially experienced some bloating, the overall improvement in my sleep quality is remarkable. I recommend this product for anyone suffering from sleep or mood issues.
7.5
Effective support
Excellent! It greatly helps my cardiovascular system and nervous system. I recommend checking with your doctor for proper dosage.
6
Supports cardiovascular function
230 people found this helpful
I've been taking this supplement to support my heart and found the effects positive. Increasing the dosage caused some restlessness in my heartbeat, so I adjusted back, but overall, magnesium is crucial for a properly functioning cardiovascular system.
0
Avoid for heart disease
10 people found this helpful
If you have cardiovascular disease, I advise against purchasing this product. I struggle with sleepless nights as my heart races after consuming coffee, and I experience symptoms of arrhythmia. Even without coffee, my heart feels unsettled, and I sought relief with this medicine. However, if you can relate to my experience, it's better not to buy it.
9
Treatment recommendation
43 people found this helpful
A doctor recommended a high-protein, low-sugar diet rich in vitamins and minerals for chronic nasopharyngitis. Magnesium is crucial, and I take nine tablets daily while my wife takes twelve. This intake helps with my wife's migraines, as well as her ongoing treatment for a serious condition related to calcium. Overall, magnesium has made significant improvements in our health.
7.5
Powerful cardiovascular support
1 people found this helpful
This is one of the best types of magnesium available. I take it in high doses to support my cardiovascular health and feel excellent effects. There are no side effects, and the price is reasonable for the large volume offered. I appreciate this product.
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
8
Magnesium linked to heart health
Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes.
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
8
Magnesium's impact on HFpEF mortality
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
8
Magnesium impacts blood sugar control
Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.
We explored the connections between magnesium (Mg), calcium (Ca), and abnormal levels of HbA1c—a key marker for blood sugar management—in adults with coronary artery disease (CAD). Our research involved a substantial group of 11,934 patients, allowing us to gain valuable insights into how these minerals impact cardiovascular health.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
References
Yu H, Zhou C, Yang S, Yu J, Zhang X, et al. Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium. Biomaterials. 2025;319:123135. doi:10.1016/j.biomaterials.2025.123135
Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
Wang F, Mao Y, Sun J, Yang J, Xiao L, et al. Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes. Sci Rep. 2025;15:4600. doi:10.1038/s41598-025-88480-9
Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
Nielsen FH. The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients. 2024;16. doi:10.3390/nu16234223
Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
Urbanowicz T, Hanć A, Frąckowiak J, Piecek J, Spasenenko I, et al. The Hypothesis of Trace Elements Involvement in the Coronary Arteries Atherosclerotic Plaques' Location. J Clin Med. 2024;13. doi:10.3390/jcm13226933
Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
Shahsavani Z, Masoumi SJ, Barati-Boldaji R, Shamshirgardi E, Kafipour R, et al. Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases. Biol Trace Elem Res. 2025. doi:10.1007/s12011-025-04587-0
Pariona-Vargas F, Mun KT, Lo EH, Starkman S, Sanossian N, et al. Is there diurnal variation in neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?. J Stroke Cerebrovasc Dis. 2025;34:108278. doi:10.1016/j.jstrokecerebrovasdis.2025.108278
Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x